This article explores the evolving discourse on the integration of homoeopathic system of medicine in perioperative care, focusing on the holistic management of patients throughout the surgical journey. Rooted in Samuel Hahnemann’s principles of individualized treatment and stimulation of the body’s healing mechanisms, homoeopathy operates on the premise that “like cures like.” Contemporary applications include addressing preoperative anxiety with medicines such as Aconitum napellus and Gelsemium sempervirens, and utilizing Arnica montana for its reputed anti-inflammatory properties during the intraoperative phase. The optimization of intraoperative comfort through homeopathy is discussed, highlighting the potential benefits of Arnica montana in minimizing side effects. Postoperative recovery involves holistic pain management using medicines like Hypericum perforatum for nerve pain and Staphisagria for wound healing. The integration of homoeopathy with conventional anesthesia, supported by medicine like Avena sativa for sedation, showcases a comprehensive approach to enhance patient well-being. It is concluded that further more comprehensive research is warranted to explore the role of homoeopathic medicines in perioperative care.