Mice (Mus musculus) have been used as a model for homeopathy research in relation to cytotoxicity, genotoxicity and carcinogenesis in our laboratory for the last three decades. Initially, anti-radiation activities of several potentized homeopathic drugs were tested against suitable controls by taking into consideration several cytogenetic endpoints. Subsequently, anti-cytotoxic, anti-genotoxic and anti-oxidative stress effects of some homeopathic drugs were tested against several chemical toxic metalloids and metal compounds. Modern techniques including Western blot, immunofluorescence, electron microscopy, UV-spectroscopy, HPLC, FTIR, NMR, RT-PCR etc were deployed to understand the possible mechanisms and pathways of action of potentized homeopathic drugs. We hypothesise that one way by which potentized homeopathic drugs act is through regulatory action on gene expression.