Edward J. Calabrese
Historical foundations of hormesis
Homeopathy, 2015, 104 (2), 83-89
The present paper provides an historical assessment of the concept of hormesis and its relationship to homeopathy and modern medicine. It is argued that the doseâresponse concept was profoundly influenced by the conflict between homeopathy and traditional medicine and that decisions on which doseâresponse model to adopt were not based on âscienceâ? but rater on historical antipathies. While the historical dispute between homeopathy and traditional medicine has long since subsided, their impact upon the field has been enduring and generally unappreciated, profoundly adversely affecting current drug development, therapeutic strategies and environmental risk assessment strategies and policies.