In a recent work Wilhelm et al. (2024) propose a therapeutic model based on the placebo effect, as they believe occurs in the practice of homeopathic medicine, according to their literature data, which suggest that homeopathic medicines contain no molecules of active principle. We do not wish here to discuss the correctness or otherwise of the proposed therapeutic model, as it is outside our expertise. Rather, we want to highlight that the hypothesis underlying their reasoning is profoundly questionable: indeed, following their view, there is no relationship between the efficacy of the therapy and the specific character of the homeopathic remedies. It is here emphasized that this relationship exists as recent available meta-analyses have shown (e.g., Hamre et al., 2023). We want to highlight that the hypothesis of Wilhelm et al. underlying their reasoning is not supported by scientific data. A detailed analysis of this proposition can be found in the recent literature (Weiermayer et al., 2022).