Aim: The purpose of the study was evaluation of quality of life (QoL) and subjective existential orientation of oncological patients.Method: 90 patients with breast (35), colorectal (10), renal (7), cerebral (7), and pancreatic (6) cancer; sarcoma (5) ; bronchial (4) cancer; lymphoma (4) ; pharyngeal (3) cancer; and others (9) underwent an elaborate medical history including questions relating to social and private circumstances. Symptoms given by patients were correlated with the signs of homeopathic evaluation of remedies as recorded in repertories (Zandvoort, Complete Repertory; MacRepertory®). Patients received individually selected homeopathic remedies in addition to regular conventional treatment. Patients were requested to complete visual analogue scales as well as a specially developed form evaluating subjective existential orientation and, finally, EORTC QLQ-C30 form version 3.0. With respect to the latter, the mean QoL improved by 0.31 points (4.33±1.54 before vs. 4.64±1.59 after additive homeopathic therapy; p=0.008, Student’s-t-Test for paired data) between first and last registered consultation which lay apart by a mean of 24 weeks. This result corresponded to an improvement of 11.6% in a seven part-series. Similar results were found for the specially developed form: The visual analogue scale showed a difference of 0.71 (5.60±2.06 before vs. 6.31±2.3 at the third consultation, p=0.043; corresponding to an improvement of 16.1% in a ten part-series), and a difference of 0.59 (5.56±2.15 vs. 6.15±2.31, p=0,007; 13.3% improvement in a ten part-series) between first and last consultation. Following the fourth consultation, analysis in 45 participants revealed that 80 % (n=36) felt an improvement of the general condition, while 20% (n=9) experienced no effect. All patients were interested in continuing homeopathic treatment.Conclusion: Homeopathy was well accepted by the investigated patients. Improvement in QoL as well as in subjective existential orientation warrants further investigations. Oncologists may want to receive information about the use of homeopathy.